Editor’s Choice – Volume 18 No 3

Precision medicine appears to be the new hot topic. In the near future, precision medicine will enable every clinician to tailor treatment and prevention strategies to an individual´s characteristics. To reach this goal, we need to collect and analyze many different types of data from many different sources, including symptoms, genomics, and brain circuitry, as well as family dynamics, environmental exposure, and cultural background.
Hans Lehrach, in a basic research article, reports that true personalization of drug therapies will rely on virtual patient models based on a detailed characterization of the individual patient by molecular, imaging and sensor techniques. This virtual patient/in silico self-model could be constructed to allow predictions about therapy response.
In another basic research article, David Gurwitz describes the evaluation of in vitro cell systems as models for human diversity, as they provide resources for personalized medicine research into neuropsychiatric disorders. He discusses the advantages and limitations of human-induced pluripotent stem cell-derived neurons, providing access to brain-specific biology. He also describes the advantages of the human lymphoblastoid cell lines derived from peripheral blood B-lymphocytes for personalized medicine research in psychiatric diseases, eg, for examining individual drug response phenotypes and genomes along with their transcriptomes, epigenomes, proteomes, metabolomes, and in vitro phenotypes.
In a translational research article, David Sweatt and Carol Tamminga review epigenetic mechanisms and their roles in conferring interindividual differences as related to experientially acquired and genetically driven changes in CNS function and their contribution to diseases.

Current Issue

September 2016 - Vol 18 - No. 3

Human Variation: From Basic Research to Personalized Medicine

In This issue

Margret R. Hoehe, MD, PhD; Pierre Schulz, MD

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From basic research to personalized medicine

Florence Thibaut (France)

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Neuropsychiatric genomics in precision medicine: diagnostics, gene discovery, and translation

Anna C. Need; David B. Goldstein (UK,USA)

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Omics approaches to individual variation: modeling networks and the virtual patient

Hans Lehrach (Germany)

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Human iPSC-derived neurons and lymphoblastoid cells for personalized medicine research in neuropsychiatric disorders

David Gurwitz (Israel)

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Individual variation in functional brain connectivity: implications for personalized approaches to psychiatric disease

Emily S. Finn; R. Todd Constable (USA)

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An epigenomics approach to individual differences and its translation to neuropsychiatric conditions

J. David Sweatt; Carol A. Tamminga (USA)

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Genomic sequencing in clinical practice: applications, challenges, and opportunities

Joel B. Krier; Sarah S. Kalia; Robert C. Green (USA)

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Personalized prescribing: a new medical model for clinical implementation of psychotropic drugs

Chin B. Eap (Switzerland)

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Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations

Seenae Eum; Adam M. Lee; Jeffrey R. Bishop (USA)

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Transforming big data into computational models for personalized medicine and health care

S. M. Reza Soroushmehr; Kayvan Najarian (USA)

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